Electrosprayed mucoadhesive alginate-chitosan microcapsules for gastrointestinal delivery of probiotics

Besides viability protection, a sufficiently prolonged gastrointestinal retention of probiotics has emerged as critically important in improving the functional effectiveness delivery these microorganisms. In this work, we formulated pure, resistant starch-reinforced and chitosan-coated alginate microparticles using an electrospray technique evaluated their performance mucoadhesive probiotic formulations for delivery. addition, designed successfully validated novel experimental set-up vitro wash-off mucoadhesion test, portable low-cost USB microscope fluorescence imaging. our pure chitosan (positive control) exhibited greatest property, whereas alginate-resistant starch ones (negative were least retentive on gastric mucosa. These electrosprayed spherically shaped, with size range 30–600 µm (60–1300 coating). Moreover, model Lactobacillus plantarum loaded alginate-starch was better protected against simulated conditions than ones, but not ones.